---
title: "Coming Soon! Core: Cell Biology Unit II"
description: "JoVE Core: Cell Biology illustrates complex cellular processes in easy-to-understand yet comprehensive animated video lessons."
---

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## Coming Soon!

# JoVE Core: Cell Biology Unit II

JoVE Core: Cell Biology illustrates complex cellular processes in easy-to-understand yet comprehensive animated video lessons. This collection focuses on the essential components and functions of cells, including organelles and membranes, cellular transport, and cell energetics.

### Upcoming Chapters

#### [Chapter 21: Principles of Cell Signaling](https://info.jove.com/core-cell-biology#ch1)

#### [Chapter 22: Signaling Networks of G Protein-coupled Receptors](https://info.jove.com/core-cell-biology#ch2)

#### [Chapter 23: Signaling Networks of Kinase Receptors](https://info.jove.com/core-cell-biology#ch3)

#### [Chapter 24: Alternative Signaling Routes in Gene Expression](https://info.jove.com/core-cell-biology#ch4)

#### [Chapter 25: The Cytoskeleton I: Actin and Microfilaments](https://info.jove.com/core-cell-biology#ch5)

#### [Chapter 26: The Cytoskeleton II: Microtubules and Intermediate Filaments](https://info.jove.com/core-cell-biology#ch6)

#### [Chapter 27: Extracellular Matrix in Animals](https://info.jove.com/core-cell-biology#ch7)

#### [Chapter 28: Cell-Matrix Interactions](https://info.jove.com/core-cell-biology#ch8)

#### [Chapter 29: Cell-cell Interactionshapter 9: Transcription: DNA to RNA](https://info.jove.com/core-cell-biology#ch9)

#### [Chapter 30: Cell Polarization and Migration](https://info.jove.com/core-cell-biology#ch10)

#### [Chapter 31: Integration of Plant Cells into Tissues](https://info.jove.com/core-cell-biology#ch11)

#### [Chapter 32: Analyzing Cells and Proteins](https://info.jove.com/core-cell-biology#ch12)

#### [Chapter 33: Visualizing Cells, Tissues, and Molecules](https://info.jove.com/core-cell-biology#ch13)

#### [Chapter 34: Cell proliferation: Control of Cycle, Division, and Growth](https://info.jove.com/core-cell-biology#ch14)

#### [Chapter 35: The Stages of Cell Division](https://info.jove.com/core-cell-biology#ch15)

#### [Chapter 36: Meiosis](https://info.jove.com/core-cell-biology#ch16)

#### [Chapter 37: Cell Death](https://info.jove.com/core-cell-biology#ch17)

#### [Chapter 38: Cancer](https://info.jove.com/core-cell-biology#ch18)

#### [Chapter 39: Stem Cell Biology And Renewal in Epithelial Tissue](https://info.jove.com/core-cell-biology#ch19)

#### [Chapter 40: A Hierarchical Stem-Cell System: Blood Cell Formation](https://info.jove.com/core-cell-biology#ch20)

#### [Chapter 41: Fibroblast Transformation and Muscle Stem Cells](https://info.jove.com/core-cell-biology#ch41)

#### [Chapter 42: Regeneration and Repair](https://info.jove.com/core-cell-biology#ch42)

#### [Chapter 43: Embryonic and Induced Pluripotent Stem Cells](https://info.jove.com/core-cell-biology#ch43)

### Want to hear from us as soon as Core: Cell Biology Unit II is released?

#### Let us know by completing the below form

#### Chapter 21: Principles of Cell Signaling

- Overview of Cell Signaling
- Types of Signaling Molecules
- Types of Receptors: Cell Surface Receptors
- Types of Receptors: Internal Receptors
- Assembly of Signaling Complexes
- Interactions Between Signaling Pathways
- Amplifying Signals via Second Messengers
- Amplifying Signals via Enzymatic Cascades
- Diversity in Cell Signaling Responses
- Cell Signaling Feedback Loops
- Cell Signaling in Plants
- Plant Hormones

[Back to the top](https://info.jove.com/core-cell-biology#Chapters)

#### Chapter 22: Signaling Networks of G Protein-coupled Receptors

- G Protein-coupled Receptors
- Activation and Inactivation of G Proteins
- GPCR Desensitization
- G-Protein Gated Ion Channels
- GPCRs Regulate Adenylyl Cylase Activity
- cAMP-dependent Protein Kinase Pathways
- IP3/DAG Signaling Pathway
- Feedback Regulation of Calcium Concentration
- Calmodulin-dependent Signaling
- Nitric Oxide Signaling Pathway

[Back to the top](https://info.jove.com/core-cell-biology#Chapters)

#### Chapter 23: Signaling Networks of Kinase Receptors

- Receptor Tyrosine Kinases
- Small GTPases - Ras and Rho
- MAPK Signaling Cascades
- The JAK-STAT Signaling Pathway
- PI3K/mTOR/AKT Signaling Pathway
- TGF- β Signaling Pathway

[Back to the top](https://info.jove.com/core-cell-biology#Chapters)

#### Chapter 24: Alternative Signaling Routes in Gene Expression

- Notch Signaling Pathway
- Canonical Wnt Signaling Pathway
- Non-Canonical Wnt Signaling Pathways
- Hedgehog Signaling Pathway
- NF-kB-dependent Signaling Pathway
- Circadian Rhythms and Gene Regulation

[Back to the top](https://info.jove.com/core-cell-biology#Chapters)

#### Chapter 25: The Cytoskeleton I: Actin and Microfilaments

- Introduction to the Cytoskeleton
- Adaptability of Cytoskeletal Filaments
- Polarity of the Cytoskeleton
- Assembly of Cytoskeletal Filaments
- Cytoskeleton Linker Proteins - Plakins
- Cytoskeletal Accessory Proteins
- Cytoskeletal Proteins in Bacteria
- Intracellular Movement of Viruses and Bacteria
- Studying the Cytoskeleton
- Introduction to Actin
- Actin Polymerization
- Actin Treadmilling
- Generation of Straight or Branched Actin Filaments
- Actin Filament Depolymerization
- Formation of Higher-order Actin Filaments
- Overview of Myosin Structure and Function
- Actin and Myosin in Muscle Contraction
- Role of Actin and Myosin in Non-muscle Cells

[Back to the top](https://info.jove.com/core-cell-biology#Chapters)

#### Chapter 26: The Cytoskeleton II: Microtubules and Intermediate Filaments

- Microtubules
- Microtubule Instability
- Microtubule Formation
- Microtubule Associated Proteins (MAPs)
- Destabilization of Microtubules
- Microtubule Associated Motor Proteins
- The Movement of Organelles and Vesicles
- Assembly of Complex Microtubule Strucutures
- Microtubules in Cell Motility
- Mechanism of Ciliary Motion
- Microtubules in Signaling
- Drugs that Stabilize Microtubules
- Drugs that Destabilize Microtubules
- The Structure of Intermediate Filaments
- Types of Intermediate Filaments
- Formation of Intermediate Filaments
- Disassembly of Intermediate Filaments
- Septins
- Role of Septins

[Back to the top](https://info.jove.com/core-cell-biology#Chapters)

#### Chapter 27: Extracellular Matrix in Animals

- The Extracellular Matrix
- Glycosaminoglycans
- Collagen are the Major Structural Proteins of ECM
- Fibril Associated Collagen
- Elastin is Responsible for Tissue Elasticity
- Fibronectins Connect Cells with ECM
- Matrix Proteoglycans and Glycoproteins
- Role of Matrix Metalloproteases in Degradation of ECM
- Basal Lamina are the Specialized Form of ECM
- Laminins are the Adhesive Proteins of Basal Lamina
- Type IV Collagen of Basal Lamina

[Back to the top](https://info.jove.com/core-cell-biology#Chapters)

#### Chapter 28: Cell-Matrix Interactions

- Overview of Cell-matrix Interactions
- Integrins
- Activation of Integrins
- Integrin-mediated Signalling
- Anchoring Junctions
- Cell-matrix's Response to Mechanical Forces

[Back to the top](https://info.jove.com/core-cell-biology#Chapters)

#### Chapter 29: Cell-cell Interactions

- Cell Adhesion Molecules — Types and Functions
- Structure of Cadherins
- Cadherins In Tissue Organization
- Catenins
- Selectins
- Immunoglobin-like Cell Adhesion Molecules
- Overview of Cell-Cell Junctions
- Adherens Junction
- Tension Response at Adherens Junctions
- Desmosomes
- Tight Junctions
- Gap Junctions

[Back to the top](https://info.jove.com/core-cell-biology#Chapters)

#### Chapter 30: Cell Polarization and Migration

- Cell Migration
- Actin-mediated Cell Motility
- Types of Membrane Protrusions
- Mechanism of Lamellipodia Formation
- Mechanism of Filopodia Formation
- Cancer Cell Migration through Invadopodia
- Cell Motility through Blebbing
- Role of Myosin Proteins in Cell Adhesion and Motility
- Cell Polarization by Rho Proteins
- Chemotaxis and Direction of Cell Migration
- The Cytoskeleton Coordinates Whole Cell Polarization and Locomotion

[Back to the top](https://info.jove.com/core-cell-biology#Chapters)

#### Chapter 31: Integration of Plant Cells into Tissues

- Plant Tissues
- Plant Cell Wall
- Tonicity in Plants
- Cellulose and Pectic Polysaccharides
- Role of Microtubules in Cell Wall Deposition
- Plasmodesmata
- Adhesion Molecules in Plants

[Back to the top](https://info.jove.com/core-cell-biology#Chapters)

#### Chapter 32: Analyzing Cells and Proteins

- Overview of Cell Separation and Isolation
- Tissue Homogenization
- Cell Culture
- Cell Lines
- Hybridoma Technology
- Subcellular Fractionation
- Flow Cytometry
- Principles Of Column Chromatography
- Types Of Column Chromatography
- Immunoprecipitation
- Tagging and Fusion Proteins
- SDS-PAGE
- Western Blotting
- 2D Gel Electrophoresis
- Enzyme-linked Immunoassay (ELISA)
- MALDI-TOF Mass Spectrometry
- Peptide Identification Using Tandem Mass Spectrometry
- X-Ray Diffraction Of Biological Samples
- Applications Of NMR In Biology
- Proteomics

[Back to the top](https://info.jove.com/core-cell-biology#Chapters)

#### Chapter 33: Visualizing Cells, Tissues, and Molecules

- Imaging Biological Samples with Optical Microscopy
- Phase Contrast and Differential Interference Contrast Microscopy
- Fixation and Sectioning
- Immunofluorescence Microscopy
- Immunocytochemistry and Immunohistochemistry
- Confocal Fluorescence Microscopy
- Protein Dynamics in Living Cells
- Total Internal Reflection
- Fluorescence Microscopy
- Atomic Force Microscopy
- Superresolution Fluorescence Microscopy
- Overview of Electron Microscopy
- Scanning Electron Microscopy
- Transmission Electron Microscopy
- Preparation of Samples for Electron Microscopy
- Immunogold Electron Microscopy
- Cryo-electron Microscopy
- Electron Microscope Tomography and Single-particle Reconstruction

[Back to the top](https://info.jove.com/core-cell-biology#Chapters)

#### Chapter 34: Cell proliferation: Control of Cycle, Division, and Growth

- What is the Cell Cycle?
- Interphase
- The Cell Cycle Control System
- Positive Regulator Molecules
- Inhibition of CDK Activity
- S-Cdk Initiates DNA Replication
- M-Cdk Drives Transition Into Mitosis
- Mitogens and the Cell Cycle
- Replicative Cell Senescence
- Abnormal Proliferation
- Cells Coordinate Growth and Proliferation

[Back to the top](https://info.jove.com/core-cell-biology#Chapters)

#### Chapter 35: The Stages of Cell Division

- Mitosis and Cytokinesis 
- Chromosome Duplication 
- Cohesins
- Condensins 
- The Mitotic Spindle 
- Centrosome Duplication 
- Spindle Assembly 
- Attachment of Sister Chromatids 
- Forces Acting on Chromosomes 
- Separation of Sister Chromatids 
- The Spindle Assembly Checkpoint 
- Anaphase A and B
- Anaphase Promoting Complex 
- The Contractile Ring 
- Determining the Plane of Cell Division 
- The Phragmoplast 
- Distribution of Cytoplasmic Content 

[Back to the top](https://info.jove.com/core-cell-biology#Chapters)

 

#### Chapter 36: Meiosis

- What is Meiosis?
- Meiosis I 
- Meiosis II
-  Meiosis vs. Mitosis
- Crossing Over
- Non- disjunction

[Back to the top](https://info.jove.com/core-cell-biology#Chapters)

 

#### Chapter 37: Cell Death 

- Overview of Cell Death 
- Apoptosis 
- Caspases
- The Extrinsic Apoptotic Pathway 
- The Intrinsic Apoptotic Pathway 
- Phagocytosis of Apoptotic Cells 
- Autophagic Cell Death 
- Necrosis

[Back to the top](https://info.jove.com/core-cell-biology#Chapters)

#### Chapter 38: Cancer

- What is Cancer?
- Cancers Originate from Somatic Mutations in a Single Cell
- Tumor Progression 
- Adaptive Mechanisms in Cancer Cells 
- The Tumor Microenvironment
- Metastasis
- Cancer-Critical Genes I: Proto-oncogenes
- Cancer-Critical Genes II: Tumor Suppressor Genes
- Loss of Tumor Suppressor Gene Function 
- The Retinoblastoma Gene
- Mechanism of Retrovirus-induced Cancers
-  Rous Sarcoma Virus (RSV) and Cancer 
- The Ras Gene 
- mTOR Signaling and Cancer Progression 
- Cancer Stem Cells and Tumor Maintenance 
- Mouse Models of Cancer Study 
- Cancer Prevention 
- Cancer Therapies 
- Targeted Cancer Therapies 
- Treatment Resistant Cancers 
- Combination Therapies and Personalized Medicine

[Back to the top](https://info.jove.com/core-cell-biology#Chapters)

#### Chapter 39: Stem Cell Biology And Renewal in Epithelial Tissue

- Zygotic Development And Stem Cell Formation
- Source And Potency Of Stem Cells
- Stem Cell Niche
- Renewal of Intestinal Stem Cells
- Role of Ephrin-Eph and Notch Signalling in Intestinal Stem Cell Renewal
- Renewal of Skin Epidermal Stem Cells
- Multipotency and Niche of Bulge Stem Cell
- Clinical Applications of Epidermal Stem Cells
- Distinctive Features of Adult Stem Cells vs Cancer Stem Cells
- Stem Cell Culture
- Tissue Renewal without Stem Cells
- Unrenewable Cells

[Back to the top](https://info.jove.com/core-cell-biology#Chapters)

#### Chapter 40: A Hierarchical Stem-Cell System: Blood Cell Formation

- Overview of the Vascular System
- Mechanism of Angiogenesis
- Regulation of Angiogenesis and Blood Supply
- Hematopoiesis
- Multipotency of Hematopoietic Stem Cells
- Lineage Commitment
- Erythropoiesis
- Differentiation of Common Myeloid Progenitor Cells
- Regulation of Hematopoietic Stem Cells

[Back to the top](https://info.jove.com/core-cell-biology#Chapters)

#### Chapter 41: Fibroblast Transformation and Muscle Stem Cells

- Connective Tissue Cell Types
- Introduction to Fibroblasts
- Mesenchymal Stem Cells
- Growth of Cartilage and Bone Tissue
- Osteoclasts in Bone Remodeling
- Overview of Skeletal Muscle
- Formation of Muscle Fibers from Myoblasts
- Satellite Stem Cells and Muscular Dystrophy

[Back to the top](https://info.jove.com/core-cell-biology#Chapters)

#### Chapter 42: Regeneration and Repair

- Overview of Regeneration and Repair
- Phases of Wound Repair
- Whole Body Regeneration
- Liver Regeneration
- Stem Cell Therapy for Tissue Regeneration
- Introduction To Nuclear Reprogramming
- Methods of Nuclear Reprogramming
- Cloning of Dolly the Sheep

[Back to the top](https://info.jove.com/core-cell-biology#Chapters)

#### Chapter 43: Embryonic and Induced Pluripotent Stem Cells

- Embryonic Stem Cells
- Maintenance of the ES Cell State
- Induced Pluripotent Stem Cells
- Somatic to iPS Cell Reprogramming
- Chromatin Modification in iPS cells
- iPS Cell Differentiation
- Forced Transdifferentiation
- EPS and iPS Cells in Disease Research

[Back to the top](https://info.jove.com/core-cell-biology#Chapters)

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