JoVE | ISSN | Research

JoVE Journal

The world’s first peer-reviewed scientific video journal indexed in PubMed, Web of Science, SciFinder, Scopus and SCI Expanded. Scientific research is published in video form alongside text protocols, bringing to life the intricate details of experimental methods.

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JoVE Encyclopedia of Experiments

This first-of-its-kind online video encyclopedia of advanced research experiments combines animations visualizing theory and videos demonstrating techniques in real university laboratories.

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Behavior ISSN 1940-087X	Includes observational and experimental approaches that seek to understand human and animal behavior.
Bioengineering ISSN 1940-087X	Publishes experimental approaches to investigate the structure, function and interactions of biological molecules.
Biochemistry ISSN 1940-087X	Features the application of engineering tools in life sciences to study biological processes and develop new therapies and diagnostics.
Biology ISSN 1940-087X	Publishes standard techniques and novel experimental approaches in the fields of cellular, molecular, and organismal biology aimed at understanding the functions of live and living organisms.
Cancer Research ISSN 1940-087X	Illustrates experimental approaches in biomedical research and clinical practice aimed at understanding, detecting, treating and preventing cancer.
Chemistry ISSN 1940-087X	Includes fundamental and applied research in organic, inorganic, analytical and physical chemistry.
Developmental Biology ISSN 1940-087X	Covers research studies of biological development at all levels, ranging from cellular to whole organisms.
Engineering ISSN 1940-087X	Dedicated to research methods across different fields of engineering, including mechanical, electrical, materials and chemical.
Environment ISSN 1940-087X	Dedicated to studies that seek to better understand Earth’s ecosystem, address environmental concerns and suggest solutions for protecting natural resources.
Genetics ISSN 1940-087X	Covers a wide array of experimental approaches used to investigate gene function, gene regulation, epigenetics, genetic disorders, population genetics and evolution.
Immunology & Infection ISSN 1940-087X	Covers studies of the immune system, mechanisms of infection, biological response to pathogens, as well as therapeutic agents and their efficacy in treating diseases.
Medicine ISSN 1940-087X	Connects biomedical research and clinical medicine featuring case studies, clinical procedures, surgeries, clinical trial methodologies and animal models of disease and treatment.
Neuroscience ISSN 1940-087X	Devoted to the study of the brain and nervous system. Also features potential treatments for neurological diseases.

Caenorhabditis elegans (worm) ISSN 2690-4454	Features research techniques for the metazoan Caenorhabditis elegans. This nematode worm is a powerful model system due to its transparent body, defined developmental plan, robust genetic tools and neuro-behavioral paradigms.
Danio rerio (zebrafish) ISSN 2690-4454	Displays various research techniques for studies using the model organism, Danio rerio, in its embryo, larva, and adult stages. These methods are used by researchers to explore a wide range of physiological and behavioral questions and create disease models for screening various chemicals.
Drosophila melanogaster (fruit fly) ISSN 2690-4454	Presents research techniques for the model organism Drosophila melanogaster at each stage of its life cycle. These methods are used by researchers to explore a wide range of physiological and behavioral questions.
Large Animal Models ISSN 2690-4454	Shows research methods using porcine, bovine, equine, and leporine (rabbit) models at their embryonic, neonatal, and adult stages. These techniques include ex-vivo and in-vivo studies, organ harvesting & preservation methods, cell isolation & culturing methodologies, microbial culturing, biochemical & biophysical assays, diagnostic tests, & various surgical procedures.
Rodent Models ISSN 2690-4454	Illustrates research methods using rodent models in embryonic, neonatal, and adult stages. The techniques include in vitro & in vivo organ perfusion, tissue and organ isolation, microbial culturing, biochemical studies, organ transplant methodologies, behavioral tests, and surgical procedures.

Breast Cancer ISSN 2767-567X	Features research techniques for the study of breast cancer. This collection includes different procedures, cell culture practices, and cancer-cell response and behavioral studies employed to advance research on breast cancer prevention, detection and treatment.
Cancers of the Nervous System ISSN 2767-567X	Indicates protocols relating to cancers originating in the nervous system. The techniques include intra-brain injections, in-vivo and in-vitro tumor modeling, cell and organelle culturing, extracellular vesicle harvesting and purification methodologies, proteomic analysis, organ isolation and preservation methods, cell migration assays, tissue engineering methods, and novel gene delivery approaches.
Colorectal Cancer ISSN 2767-567X	Highlights some fundamental research techniques in colorectal cancer relating to screening tests, genetic analysis, studies on the gut microbiome, therapeutic interventions, animal model generation, assay techniques, and cell behavior & metastatic responses.
Gastrointestinal Cancer ISSN 2767-567X	Identifies protocols relating to cancers originating in the regions or organs associated with the gastrointestinal tract. The collection comprises research protocols on cell isolation, culturing, and adhesion studies, tissue staining and histological analysis, DNA methylation studies, tissue preservation methods, exosome analysis, and generation of animal models.
Gynecologic Cancer ISSN 2767-567X	Showcases protocols relating to the prevention, detection, and treatment of cancer originating from cells or regions of the female reproductive system. The protocols are relevant for cancer-targeting and detection approaches, metabolic assessment of cancer cells, developing in vivo and metastatic animal models, in vitro cell culture and assay techniques, and transplantation experiments.
Head and Neck Cancer ISSN 2767-567X	Includes protocols relating to head and neck cancer modeling in vitro, in ovo, and in vivo, cell isolation and culture, fluorescent in situ hybridization-related techniques, generation of decellularized tissue matrices, and drug-resistance characterization assays.
Leukemia ISSN 2767-567X	Highlights a set of in vitro assay techniques to analyze leukemic cell growth and metabolism, cell isolation and culture methods, approaches to characterize and study cellular morphology, and genetic manipulation procedures.
Lung Cancer ISSN 2767-567X	Covers techniques relating to the generation of lung cancer animal models, cancer cell characterization, treatment and detection strategies, in vitro culture studies, assays and isolation techniques that facilitate lung cancer research.
Pancreatic Cancer ISSN 2767-567X	Presents protocols demonstrating the generation of pancreatic animal models, genetic engineering of pancreatic cancer cells, methods for in vitro modeling of pancreatic cancer, cell isolation and characterization techniques, and tumor cell behavior and response studies.
Prostate Cancer ISSN 2767-567X	Displays techniques employed in prostate cancer research relating to cancer cell/organoid culture, processing and staining, cell and tissue sampling, organ extractions, in vivo & in vitro cancer modeling, and cancer proteomics studies.
Skin Cancer ISSN 2767-567X	Focuses on research approaches relating to melanoma and other types of skin cancer. The protocols feature techniques relevant to developing in vitro and in vivo skin carcinogenesis and metastatic models, cell culturing, skin regeneration approaches, genetic manipulation and sensitivity studies using skin cells, and assay techniques.
Urinary Tract Cancer ISSN 2767-567X	Exhibits protocols relating to cancers originating in the regions or organs of the urinary or renal system. The techniques include organs, tissue, and cell harvesting procedures, organotypic culturing approaches, in vivo cancer modeling studies, decellularized tissue matrix generation, stem cell–related and electrophysiology studies, genetic-engineering strategies, tissue staining and imaging techniques, and protein expression analysis.

Assay Techniques ISSN 2834-8400	Feature various bioanalytical techniques to assess the activity, potency, or localization of test substances in living organisms performed at the macromolecular, sub-cellular, cellular, or organism level. Assay outcomes are detected directly or indirectly by visualizing the responses via colorimetric, enzymatic, or electrophysiological measurement methods.
Biomolecular Interaction Detection Techniques ISSN 2834-8400	Demonstrate various methods and techniques used to study protein-protein interactions. These approaches encompass scientific tools and technologies, such as biosensors, imaging techniques, assays, and spectroscopy, that provide insights into the intricate world of protein interactions and their roles in biological systems, enabling a deeper understanding of the events that transpire at the molecular level. These interactions are fundamental in numerous cellular activities, including signal transduction, enzymatic reactions, gene regulation, and structural organization.
Blot Techniques ISSN 2834-8400	Encompass a variety of meticulous methods employed for the quantification and detection of biomolecules, spanning DNA, RNA, and proteins, contributing to a comprehensive understanding of biological systems. This collection features diverse applications, including the precise quantification and detection of biomolecules, assessing genetic material, examining epigenetic modifications, and measuring protein expression levels.
Chromatography Techniques ISSN 2834-8400	Explain the mechanisms behind separating and purifying various analytes such as proteins, lipids, carbohydrates, antibody-drug conjugates, and small molecules from complex mixtures using column, capillary, or plate-based systems. The highlights include chromatographic separation methods using ion exchange, standard and reverse-phase, affinity, size-exclusion, gas-based, and thin-layer dependent techniques.
Electrophoresis Techniques ISSN 2834-8400	Highlight the mechanisms behind various electrophoresis techniques to separate biomolecules such as DNA, RNA, peptides, individual proteins, protein complexes, and amyloids. These methods utilize variants of agarose gel- or polyacrylamide gel-based matrices to separate biomolecules under the influence of an electric field.
Gene Transfer Techniques ISSN 2834-8400	Showcase gene transfer methods, including viral vector-mediated transduction and non-viral vector-mediated physical and chemical transfection techniques to deliver genetic material in cultured cells and in vivo animal models at their embryonic and adult stages. Highlights include transfection utilizing hydrodynamics, microinjection, biolistics, nucleofection, and magnetofection techniques, and transduction via retroviral, adenoviral, nanoblade, and lentiviral systems.
Genome Editing Techniques ISSN 2834-8400	Cover techniques used for genome editing in cultured bacterial, animal, and plant cells and in vivo animal models. These methods highlight the applications of CRISPR technology, Zinc finger nucleases, TALENs, transposition and recombination events, shRNA, siRNA, and vector-based transformations to achieve gene knock-in, gene knock-out, and gene regulations.
Microscopy Techniques ISSN 2834-8400	Comprise an array of advanced experimental techniques in the field of microscopy and imaging, aimed at investigating various biological and cellular processes. These techniques enable researchers to visualize and study dynamic cellular events, molecular interactions, and structural features with high resolution and specificity.
PCR Techniques ISSN 2834-8400	Extend to a range of applications and methods that utilize Polymerase Chain Reaction (PCR) to identify and examine genetic markers, mutations, and sequences. These techniques encompass mutation detection, annealing temperature optimization, genetic marker quantification, infection diagnosis, enumeration of infective particles, nucleic acid amplification, analysis of epigenetic modifications, and detection of transcript variants.
Spectroscopy Techniques ISSN 2834-8400	Highlight various spectroscopy techniques that are relevant in molecular biology. Based on the principle that molecules absorb or emit light at specific wavelengths or frequencies, spectroscopy allows for the measurement of light absorption, emission, or scattering. These techniques provide valuable insights into the composition, structure, interactions, and dynamics of molecules involved in biological processes.
Staining Techniques ISSN 2834-8400	Feature methods for staining biomolecules such as lipids, carbohydrates, and proteins; and different cell types ranging from individual plant or animal cells to various tissue sections. These methods help visualize and characterize a wide variety of biological samples by improving their contrast.

Antibody-Based Technologies ISSN 2994-5631	Covers antibody production, purification, functionality assays, and applications in imaging, detection, and analysis, aiding researchers in advancing biomedical discoveries and therapies.
Immune Systems and Components ISSN 2994-5631	Feature experimental procedures for isolating, culturing, differentiating, and analyzing immune cells, exploring the immune system using human and mouse models.
Immune Response ISSN 2994-5631	Explores immune responses, including pathogen interactions, inflammation, receptor signaling, and cell activation. Using techniques like flow cytometry and immunoassays, it provides insights into immune system dynamics during infections, treatments, and stimuli.
Immunopathology ISSN 2994-5631	Examines pathogen-immune system interactions, immune responses, and disease development using in vivo and ex vivo models. It highlights techniques to study immunopathology, advancing therapeutic interventions and understanding of immune-related diseases.
Immunodiagnostics ISSN 2994-5631	Presents assays to study immune responses and immunomodulation, covering bacterial infection detection, cytotoxicity, cell interactions, and cytokine bioactivity. Using imaging, flow cytometry, and fluorescent assays, it aids in understanding immune function and developing therapies.
Immunotherapy ISSN 2994-5631	Showcases immunotherapy protocols, including CAR T-cell production, siRNA treatments, and novel vaccines. Techniques like CRISPR and viral transduction advance understanding and treatment of complex diseases, driving immunotherapy innovation.

Neuronal Cultural Techniques ISSN 3065-5374	Cover neuronal culture techniques, from basic neuron cultures to advanced methods like 3D scaffolds, microfluidics, and brain organoids. It includes co-cultures for studying neuron-glia interactions, synapse formation, and neurogenesis in vitro.
Neurophysiology ISSN 3065-5374	Feature methods to study neural function, including electrical activity recording, optical techniques for dynamic visualization, and stimulation tools like electrical, magnetic, and optogenetics to examine and modulate neural circuits.

ISSN Catalogue

JoVE Journal

JoVE Encyclopedia of Experiments

JoVE Journal

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JoVE Encyclopedia of Experiments

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